Abstract:
In the present project, we studied the design of an appropriate strategy for the preparation of cyclobutenes by means of Lewis acid catalysis. In particular the Ficini stepwise [2+2] cycloaddition of ynamides with lactones was taken under consideration as an excellent reaction for the preparation of substituted cyclobutene derivates. The synthesis of a novel cyclobutene derivate has been carried out, with good yield. On the other hand, the synthesis of other derivates, such as a nucleoside analogue, will require further investigation.
