Drug delivery system for the treatment of burn injuries

Abstract

With the advancements in medicine, various solutions have been proposed to treat skin burns. But serious burns interesting a large area of body surface remain a major cause of subsequent infections because of several factors, such as poor penetration of drugs through skin barrier, availability of bacterial nutrients in the burned area, destruction of the vascular supply to the burned skin. All these factors jointly make burns vulnerable to infection. To overcome these factors and other limitations of conventional burn injury treatments, we have proposed a formulation. In the present study, we have formulated an efficient drug delivery system to prevent infections on burn wounds and to improve the skin penetration of our model drug(Silver Sulfadiazine(AgSD)). Our system is based on a nanoporous matrix formulated by a sustainable sol-gel approach. The formulation is made of silica/chitosan alongside some other ingredients which are reported to be good penetration enhancer for drugs and are also beneficial for the treatment of burn injuries.